Vaginal route is one of the underutilized route of administration which is known since ancient time, but nowadays it is gaining importance because of advanced formulation technologies which include effervescent technology, Bio-adhesive technology and vaginal rings. Vaginal route remains a promising route when the drug undergoes gastric disintegration (Progesterone) and hepatic first pass (Estrogen). But VDDS remains less patient compliance compared to other routes so newer formulation techniques are required to ensure increased patient compliance.
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